By
| 21/08/2021 | 12:30 | Liverpool FC | – | Burnley FC | 2:0 (1:0) | |
| 15:00 | Aston Villa | – | Newcastle United | 2:0 (1:0) | ||
| 15:00 | Crystal Palace | – | Brentford FC | 0:0 (0:0) | ||
| 15:00 | Leeds United | – | Everton FC | 2:2 (1:1) | ||
| 15:00 | Manchester City | – | Norwich City | 5:0 (2:0) | ||
| 17:30 | Brighton & Hove Albion | – | Watford FC | 2:0 (2:0) | ||
| 22/08/2021 | 14:00 | Southampton FC | – | Manchester United | 1:1 (1:0) | |
| 14:00 | Wolverhampton Wanderers | – | Tottenham Hotspur | 0:1 (0:1) | ||
| 16:30 | Arsenal FC | – | Chelsea FC | 0:2 (0:2) | ||
| 23/08/2021 | 20:00 | West Ham United | – | Leicester City | 4:1 (1:0) |
